![]() ![]() That’s a short timeframe, but at the same time glioblastomas are nearly 100% fatal, so any improvement in medical care is major progress,” Eriksson concluded. If I’m optimistic, perhaps it might take five years. “It largely depends on whether funding comes in that allows taking the different steps as smoothly as possible. But Leif Eriksson hopes and believes that it should go relatively quickly to get the pharmaceutical into clinical treatment. There is still much to do, such as optimizing the treatment procedure and additional animal experiments. Research on this molecule will now continue. While more in-depth studies are needed, extensive cell tests have shown that the substance is non-toxic for healthy cells even at very high doses. The treated animals maintained weight, had no apparent changes in behavior and there was no sign of impact on the liver. With this new treatment, the researchers have not yet seen any side effects with the substance. No side effects for this new brain tumor treatmentĬurrent treatments for brain tumors often have severe side effects. This new method does not work with these forms of cancer. There are other types of brain tumors that develop differently than glioblastomas. We have also begun studying the use of our substance on other aggressive tumor forms like pancreatic cancer, triple-negative breast cancer and certain lever cancers,” says Eriksson. “These are the first clear results with brain tumors that can lead to a treatment which completely avoids surgery and radiation. In comparative experiments with just chemotherapy, the brain tumors relapsed after 100 days and grew rapidly. Since the tumors were stressed to death, all cancer cells disappeared, and in animal experiments with mice there was no cancer relapse after 200 days. The researchers saw that a combination treatment with the new substance and chemotherapy was enough to completely kill the tumors while also preventing relapse. Studies with the new method have shown very promising results. Combo: Combination treatment with chemotherapy and the inhibitor Z4P. TMZ: Follow-up treatment solely with chemotherapy. Three pictures show the spread of the tumor after 20 days of treatment on mice. This inhibition causes the cancer cell to die. The researchers’ molecule Z4P inhibits one of the mechanisms that regulate protein production in a cancer cell. Once the cancer relapse, the tumor cells have often spread and developed resistance,” Eriksson said. Unfortunately, all cancer cells are not killed and the tumor returns. “Today, cancer treatment consists of surgery, radiation and chemotherapy. Only a few percent survive five years after diagnosis and treatment. Currently, the prognosis for malignant glioblastomas is very bad. For the EU as a whole, there are 19,000 cases annually. These make up about 45% of all brain tumors and around 400 Swedes are diagnosed with glioblastomas every year. ![]() The breakthrough applies to glioblastoma brain tumors. They presented their findings in the journal iScience. Using super computers and advanced simulations, the researchers developed a version of the molecule that can also pass through the blood-brain barrier that protects brain tissue. Swedish-French collaborationĮriksson’s group has worked with a research group at INSERM in Rennes, France. This causes the cancer to self-destruct,” says Leif Eriksson, professor of physical chemistry at the University of Gothenburg. ![]() “We have now succeeded in stopping this hijacking by inserting a specially developed molecule in the cells that inhibits one of these hijacked adaptive mechanisms in the cancer cells. Without these hijacked mechanisms, the cancer cell would die. To manage this stress, the cancer cells hijack mechanisms that the healthy cells use to regulate protein production and process the surplus proteins that they create. By blocking certain functions in the cell with a docked molecule, the researchers cause the cancer to die of stress.Ĭancer cells, especially those that form aggressive tumors, are in one way or another out of control and live a very stressful existence. Researchers at the University of Gothenburg in Sweden, working with French colleagues, have successfully developed a method able to kill the aggressive brain tumor glioblastoma. ![]()
0 Comments
Leave a Reply. |